Pharmaceutics Books
Pharmaceutical Preformulation
Contents
- The Innovator Company
- Patent Considerations
- Biological Equivalence and the Principle of (Patent) Equivalence
- Pharmaceutical Preformulation
- Molecular Investigation in Later Phases
- Macroscopic Property Determination in Later Phases
- Statistics and Optimization of Protocols
- Computer Programs
- Analytical Techniques
- Solubility
- Aqueous Solubility of Non-Ionized Drugs
- Solubility Determinations by RH-Relations
- Solubility in mixed solvents
- Solubility of Drug Substances which Ionize in Solution
- Ionic Strength
- Solubility Determinations when Adequate Supplies of Drug Substance are Available
- Solubility of Poorly Stable Compounds
- Effect of Surfactants
- Mixed Solvent Systems as a Formulation Aid in Solubilization
- Partition Coefficients
- Dielectric Constant and Solubility Parameters
- Solubility and pH
- Curved Van't Hoff Plots
- Preformulation Tasks in the Area of Solubility
- pH and pK
- Definition of pH
- Obtaining pK
- Approximate Relation between pKa and pK(c)
- Spectrophotometric Determination of pK
- Solubility of a Weak Electrolyte as a Function of pH
- Partition Coefficients of Weak Electrolytes
- Preformulation Tasks
- Surface Tension and Critical Micelle Concentration
- Instrument Properties
- Surface Tension
- Critical Micelle Concentration
- Effect of Temperature on CMC-Values
- Effect of Counter Ion on Surface Tension
- Effect of Temperature on Surface Tension
- General Impact of Amphiphilic
- Solution Kinetics
- Preliminary Task
- Reaction Order
- Fractional Lives
- Temperature Effects
- Effect of Reaction Mechanisms
- Calorimetric Methods
- pH Profiles and Buffer Effect
- Oxidation
- Kinetic Salt Effect
- Amphiphilic Drugs
- Optimization
- Preformulation Check Sheet
- Suspensions
- Solubility
- Rationale for Suspensions
- Taste
- Stability
- Viscosity
- Settling of Suspensions
- Sedimentation Kinetics
- Density Matching
- Particle Growth
- Rheograms
- Yield Diameter of Suspensions
- Protective Colloids
- Adsorption Isotherms
- Coascervates
- Surfactants
- Preservation and Surface Adsorption
- Dissolution of Suspensions
- Content Uniformity
- Pre-NDA and Pre-ANDA Testing
- Initial Specifications
- Test Post-NDA and Post-ANDA
- Production Problems
- Crystalline Solids
- Crystal Systems
- Drug Purification
- Crystal Habit
- Vapor Pressure of Solids
- Solubility Measurements
- Polymorphism by Solubility Measurements
- Metastable Solutions
- Differential Scanning Calorimetry (DSC)
- Preformulation Tasks
- Drug Substance Considerations
- Salt Selection
- Purifacation by Perticipation
- Purity Assessment by Means of Phase Solubility
- Differential Scanning Calorimetry (DSC)
- Eutectic Diagrams
- Preformulation Tasks
- Moisture Isotherms
- Water Adsorption
- Classifacation of Solids in Regards to Moisture
- Critical Moisture Content(RH*)
- Moisture Uptake below the Critical RH
- Automated Equipment
- Isotherms of "Soluble" Compounds
- Hydrates
- Hygroscopicity
- Solubilities from Moisture Isotherms
- Preformulation Tasks
- Nomenclature
- Principles of Dissolution
- The Noyes-Whitney Equation
- The Dissolution Rate "Constant"
- Particulate Dissolution
- Multiparticulates
- Equivalent "Diameters"
- Preformulation Tasks
- Micromeritics
- Microscopy
- Geometric Surface Areas
- Sieve Analysis
- Surface Areas
- Preformulation Tasks
- Shape Factors
- Geometric Surface Area and Rugosity
- Microscopically Determined shape Factors
- The Ridgeway-Rupp Experiments
- Shape Factors in General
- Dimensional Microscopic Shape Factors
- Fractal Geometry
- Fractal Analysis and Pharmaceutical Parameters
- Preformulation Tasks
- Physical Testing
- Pharmaceutical Equipment for Solid Dosage Forms
- Hard Shell Capsules
- Dissolution of Capsules
- Routine Task with Hard Shell Capsules
- Soft Shell Capsules
- Tablets
- Mechanical Testing of Solid Dosage Forms
- Disintegration Test
- Tablets-Dissolution
- Physical Compatibility
- Some Routine Tests
- Weight and Content Uniformity
- Apparent Density of Mixtures
- Cohesion-Repose Angles
- Sieve Analysis
- Effects of Polymorphism
- Preformulation Tasks
- Compatibility Testing
- Compatibility Test for Solid Dosage Forms
- Hydrates
- Dissolution Compatibility
- Vapor Pressure
- Aqueous Solution Compatibility
- Non-Aqueous Liquids
- Preformulation Task
- Dissolution Test Design
- In vitro Dissolution of Solid Dosage Forms
- Blood Level Equations
- In vivo Dissolution
- Calculating the Correlating in vitro Curve
- Calculating the Correlating in vitro Curve
- One Point Methods and Deconvolution
- Symbols
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